parkinson disease — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7626	Budipine		Others
	Budipine is a low affinity, N-methyl-D-aspartate receptor antagonist,is an antiparkinsonian agent.		Others
T9346	CVN424		GPR
	CVN424 is a selective and novel GPR6 Inverse agonist effective in models of Parkinson Disease.		GPR
T8849	PF-9601N		MAO
	PF-9601N showed high potency and selectivity as a MAO-BI (monoamine oxidase type B inhibitor) and also demonstrated remarkable neuroprotective properties in several in vivo and cellular models of PD.		MAO
T8975	PSB-SB-487		Cannabinoid Receptor
	PSB-SB-487 is antagonist of GPR55.		Cannabinoid Receptor
T9228	Propionylpromazine hydrochloride	Propiopromazine hydrochloride	Dopamine Receptor
	Propionylpromazine hydrochloride (Propiopromazine hydrochloride) is a dopamine receptor D2 (DRD2) antagonist.		Dopamine Receptor
T8869	B355252		Others
	B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.		Others
T22103	ML-193	CID 1261822	Cannabinoid Receptor
	ML-193 (CID 1261822) is a potent and selective GPR55 antagonist( IC50 : 221 nM). It shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2, and can improve the motor and the sensorimotor deficits of Parkin...		Cannabinoid Receptor
T37792	A2A receptor antagonist 1	CPI-444 analog,A2A receptor antagonist 1	Adenosine Receptor
	A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Kis of 4 and 264 nM, respectively.		Adenosine Receptor
T0920	Ambroxol	Ambroxolum,NA-872	P450 , Autophagy
	Ambroxol (NA-872) is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a muco...		P450 , Autophagy
T6234	Ambroxol hydrochloride	Mucosolvan,Mucoangin,Ambroxol HCl	Sodium Channel , Autophagy
	Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.		Sodium Channel , Autophagy
TN2011	Ombuoside	Ombuin-3beta-rutinoside	Antibacterial
	Ombuoside (Ombuin-3beta-rutinoside) has antifungal activity. Ombuoside shows significant antioxidant activity in the DPPH, and TEAC, reducing power assays.Ombuoside is a glycoside ombuoside isolated from Gynostemma penta...		Antibacterial
T7002	Trihexyphenidyl hydrochloride	Triesifenidile,Benzhexol hydrochloride,Tremin,Artane hydrochloride	AChR
	Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) is an antiparkinsonian agent of the antimuscarinic class.		AChR
T4024	Norharmane	2-Azacarbazole,2,9-Diazafluorene,β-Carboline	DNA , Endogenous Metabolite , Monoamine Oxidase
	Norharmane (β-Carboline) is a natural β-carboline first isolated from plants of the Zygophyllaceae family.		DNA , Endogenous Metabolite , Monoamine Oxidase
T5678	Lazabemide hydrochloride	N-(2-Aminoethyl)-5-chlor-2-pyridincarbox	MAO , Monoamine Oxidase
	Lazabemide hydrochloride (N-(2-Aminoethyl)-5-chlor-2-pyridincarbox) is a reversible and selective mao-b inhibitor(Ki：7.9nM).		MAO , Monoamine Oxidase
T24047	Etilevodopa hydrochloride	Levodopa ethyl ester,Etilevodopa HCl, L-DOPA ethyl ester	Others , Dopamine Receptor , Drug Metabolite
	Etilevodopa hydrochloride (L-DOPA ethyl ester) is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.		Others , Dopamine Receptor , Drug Metabolite
T9409	Mesdopetam hemitartrate	IRL790 hemitartrate,1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)	Dopamine Receptor
	Mesdopetam hemitartrate (IRL790 hemitartrate) is an antagonist of dopamine D3 receptor (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor). It has psychomotor stabilizing properties.		Dopamine Receptor
T5470	LAZABEMIDE	Ro 19-6327	MAO , Monoamine Oxidase
	Lazabemide (Ro 19-6327) is selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively).		MAO , Monoamine Oxidase
T12525	Pozanicline dihydrochloride	ABT-089 dihydrochloride	AChR
	Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable agonist of nicotinic acetylcholine receptor (nAChR) (Ki = 16.7 nM)		AChR
T1628	Rivastigmine tartrate	SDZ-ENA 713,ENA 713	AChR , AChE
	Rivastigmine tartrate (SDZ-ENA 713) is a carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHEIMER DISEASE and PARKINSON...		AChR , AChE
T1751	Eliprodil	SL-820715	NMDAR , iGluR
	Eliprodil (SL-820715)(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has been used in trials studying the treatment of Pa...		NMDAR , iGluR